The final round of matches to compete for the remaining three slots for Africa ahead of next year’s football World Cup in Russia, will kick off later today.
Egypt and Nigeria have already qualified, while Tunisia and Senegal are almost there.
Senegal could be the first to qualify if they win away against South Africa to guarantee top spot in Group D.
The match in Polokwane is a replay of last year’s 2-1 win for South Africa at the same venue.
Football’s world governing body, Fifa, ordered a repeat of the game after it found the result was manipulated by Ghanaian referee Joseph Lamptey, who has since been handed a life ban.
It means Senegal and South Africa play each other twice in the space of four days with a return encounter next Tuesday in Dakar.
Senegal need one point from the two games and South Africa coach Stuart Baxter admits that he and his side are underdogs to qualify for Russia.
Here’s a list of other matches to look out for:
Group D – South Africa v Senegal – 1700GMT
Group B – Algeria v Nigeria – 1930GMT
Group B: Zambia v Cameroon – 1300GMT
Group C – Gabon v Mali – 1430GMT
Group A – Tunisia v Libya – 1730GMT
Group A – DR Congo v Guinea – 1730GMT
Group C – Ivory Coast v Morocco – 1730GMT –
Group E – Congo v Uganda – 1430GMT
Group E – Ghana v Egypt – 1530GMT
Group D – Senegal v South Africa – 1930GMT
Group D – Burkina Faso v Cape Verde – 1930GMT